Robert Segal Selected Research

lucinactant

11/2012	A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure.
10/2010	An open label, pilot study of Aerosurf® combined with nCPAP to prevent RDS in preterm neonates.
9/2010	Pulmonary distribution of lucinactant and poractant alfa and their peridosing hemodynamic effects in a preterm lamb model of respiratory distress syndrome.
1/2009	A pilot randomized, controlled trial of later treatment with a peptide-containing, synthetic surfactant for the prevention of bronchopulmonary dysplasia.
6/2007	One-year follow-up of very preterm infants who received lucinactant for prevention of respiratory distress syndrome: results from 2 multicenter randomized, controlled trials.
4/2005	A multicenter, randomized, masked, comparison trial of lucinactant, colfosceril palmitate, and beractant for the prevention of respiratory distress syndrome among very preterm infants.
4/2005	A multicenter, randomized, controlled trial of lucinactant versus poractant alfa among very premature infants at high risk for respiratory distress syndrome.

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Robert Segal Research Topics

Disease

8	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 11/2019 - 04/2005
4	Acute Lung Injury 01/2020 - 10/2006
3	Lung Injury 01/2020 - 10/2006
3	Bronchopulmonary Dysplasia 01/2020 - 01/2009
3	Heart Failure 01/2020 - 04/2003
3	Respiratory Insufficiency (Respiratory Failure) 11/2019 - 10/2010
3	Erectile Dysfunction 03/2017 - 02/2011
2	Hypotension (Low Blood Pressure) 01/2020 - 10/2010
2	Pneumonia (Pneumonitis) 11/2017 - 01/2009
2	Non-Muscle Invasive Bladder Neoplasms 09/2013 - 09/2010
2	Bradycardia 11/2012 - 10/2010
2	Urinary Bladder Neoplasms (Bladder Cancer) 04/2012 - 09/2010
2	Hemorrhage 04/2006 - 04/2005
1	Injection Site Reaction 01/2020
1	Hyperoxia 01/2020
1	Body Weight (Weight, Body) 01/2015
1	Pulmonary Edema 01/2015
1	Surfactant Dysfunction 11/2012
1	Hypoxia (Hypoxemia) 11/2012
1	Carcinoma (Carcinomatosis) 04/2012
1	Prostatic Neoplasms (Prostate Cancer) 02/2011
1	Cognitive Dysfunction 09/2005
1	Hypercalcemia (Milk Alkali Syndrome) 09/2005
1	Periventricular Leukomalacia (Neonatal Cerebral Leukomalacia) 04/2005
1	Birth Weight (Birth Weights) 04/2005
1	Newborn Respiratory Distress Syndrome 04/2005

Drug/Important Bio-Agent (IBA)

8	Surface-Active Agents (Surfactants)IBA 01/2020 - 04/2005
7	lucinactantIBA 11/2012 - 04/2005
5	Peptides (Polypeptides)IBA 11/2012 - 10/2006
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2005
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 11/2017
2	KL4 surfactantIBA 11/2017 - 10/2006
2	Oxygen (Dioxygen)IBA 11/2012 - 01/2009
2	poractant alfa (Curosurf)FDA Link 09/2010 - 04/2005
2	beractant (Survanta)FDA Link 10/2006 - 04/2005
1	AerosolsIBA 01/2020
1	Vitamin A (Retinol)FDA LinkGeneric 01/2020
1	IstaroximeIBA 01/2020
1	CytokinesIBA 11/2017
1	Irritants (Vesicants)IBA 01/2015
1	PhosgeneIBA 01/2015
1	TOR Serine-Threonine KinasesIBA 09/2013
1	ArginaseIBA 11/2012
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 09/2010
1	Oxidants (Oxidizing Agents)IBA 01/2009
1	tyloxapol drug combination hexadecanol dipalmitoylphosphatidylcholine (Exosurf Neonatal)FDA Link 06/2007
1	Pulmonary Surfactants (Pulmonary Surfactant)IBA 10/2006
1	sinapultideIBA 10/2006
1	Phospholipids (Phosphatides)FDA LinkGeneric 10/2006
1	LipidsIBA 10/2006
1	LipopolysaccharidesIBA 10/2006
1	TeaIBA 04/2006
1	Warfarin (Coumadin)FDA LinkGeneric 04/2006
1	Pamidronate (Aredia)FDA LinkGeneric 09/2005
1	Losartan (Cozaar)FDA LinkGeneric 07/2005
1	Captopril (Capoten)FDA LinkGeneric 07/2005
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 07/2005
1	colfosceril palmitate FDA Link 04/2005
1	Uric Acid (Urate)IBA 04/2003

Therapy/Procedure

8	Therapeutics 01/2020 - 06/2007
2	Continuous Positive Airway Pressure 11/2019 - 10/2010
1	Intramuscular Injections 01/2020
1	Retreatment 11/2012
1	Artificial Respiration (Mechanical Ventilation) 11/2012
1	Cystectomy 04/2012
1	Prostatectomy (Retropubic Prostatectomy) 02/2011